cofactor

1. A contributing factor.

2. A substance, especially a coenzyme or a metal, that must be present for an enzyme to function.

   a substance (as a coenzyme) that must join with another to produce a given result

3. A molecule that binds to and regulates the activity of a protein.

4. The result of a number being divided by one of its factors.

5. The signed determinant of the submatrix produced by removing the row and column containing a specified element; primarily used in the recursive definition and calculation of the determinant of a matrix.

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