helix-loop-helix
A structural motif where two alpha helices are connected by a highly flexible amino…A structural motif where two alpha helices are connected by a highly flexible amino acid loop, allowing the helices to pack together. Usually requires forming a dimer with another HLH protein before binding DNA.
Meaning
1 sensesA structural motif where two alpha helices are connected by a highly flexible amino acid loop, allowing the helices to pack together. Usually requires forming a dimer with another HLH protein before binding DNA.
Origin
From helix + loop + helix. The term got its name from its distinct physical geometry; twoFrom helix + loop + helix. The term got its name from its distinct physical geometry; two alpha helices separated and connected by a flexible chain of amino acids known as a "loop", allowing the helices to pack together tightly.
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